Researcher Profile and Settings

Name

• Name

  NAKAMURA Akio

Researcher Profile and Settings

Research Areas

• Molecular Nutrition, Molecular Biology, Cell Biology, Biochemistry, Pharmacology, Environmental Science, Paleontology, Geology

Researcher Profile and Settings

Published Papers

• Unveiling the Threat of Maternal Advanced Glycation End Products to Fetal Muscle: Palmitoleic Acid to the Rescue., 2024, Hitomi Yoshizaki, Ritsuko Kawaharada, Saki Tsutsumi, Haruka Okami, Akiyo Toriumi, Eri Miyata and Akio Nakamura, Nutrients, 16, 12, 1898
• 胎生期の過栄養と栄養シグナル：DOHaD 先制医療への展開, 2023, Akio Nakamura, Ritsuko Kawaharada
• Maternal n-7 Unsaturated Fatty Acids Protect the Fetal Brain from Neuronal Degeneration in an Intrauterine Hyperglycemic Animal Model., 2023, Haruka Okami, Ritsuko Kawaharada, Hitomi Yoshizaki, Akiyo Toriumi, Saki Tsutsumi and Akio Nakamura, Nutrients, 15, 15, 3434 - 3455
• 子宮内高血糖環境が次世代に及ぼす影響と先制医療, 2023, Akio Nakamura, Ritsuko Kawaharada, 11, 2, 117 - 125
• DOHaD研究への憧憬と学会との出会い, 2023, Akio Nakamura, 11, 1, 26 - 27
• Inflammatory Diseases and the Role of n-7 Unsaturated Fatty Acids as Functional Lipids, 2022, Akio Nakamura, Hikari Nakamura, and Ritsuko Kawaharada, IntechOpen
• Effects of omega-7 palmitoleic acids on skeletal muscle differentiation in a hyperglycemic condition., 2021, Tokunaga, Y., Yoshizaki, H., Toriumi, A., Kawaharada, R., Ishida, C., Hori, M., Nakamura, A., The Journal of Veterinary Medical Science, 83, 9, 1369 - 1377
• 2021, 16, 50 - 56
• Future Risks for Children Born to Mothers with Gestational Diabetes: Elucidation Using the Cell Model Approach. : Gestational Diabetes Mellitus - New Developments, 2021, IntechOpen, 137 - 152
• 2021, 21, 2, 73 - 75
• Advanced Glycation End Products and Oxidative Stress in a Hyperglycaemic Environment. : Fundamentals of Glycosylation, 2021, Nakamura, A. and Kawaharada, R., IntechOpen, 9 - 32
• Effects of Palmitoleic acids on skeletal muscle differentiation in hyperglycemic environment., 2021, Tokunaga Yayoi;Yoshizaki Hitomi;Toriumi Akiyo;Ishida Chisato;Kawaharada Ritsuko;Hori Masatoshi;Nakmura Akio, Proceedings for Annual Meeting of The Japanese Pharmacological Society, Japanese Pharmacological Society, 94, 0, 3 - P2-28
• 2020, 42, 4, 310 - 318
• Effects of saturated fatty acids on skeletal muscle differentiation in an intrauterine hyperglycemic environment, 2020, Yayoi Tokunaga;Kawaharada Ritsuko;Ishida Chisato;Nakamura Akio, Proceedings for Annual Meeting of The Japanese Pharmacological Society, Japanese Pharmacological Society, 93, 0, 1 - P-079
• Effects of AGEs on the rat neuronal cells in the intrauterine hyperglycaemic environment., 2020, Nakamura Akio;Okami Haruka;Shimizu Manami;Ooi Satomi;Tokunaga Yayoi;Sasaki Yo;Kawaharada Ritsuko, Proceedings for Annual Meeting of The Japanese Pharmacological Society, Japanese Pharmacological Society, 93, 0, 2 - P-192
• 糖尿病妊娠モデル動物を用いた子宮内高血糖環境が次世代に与える影響, 2019, 河原田律子, 小浜智子, 中村彰男, 糖尿病と妊娠, 19, 2, 49 - 52
• 子宮内高血糖がラット新生仔の神経細胞に与える影響, 2019, 糖尿病と妊娠, 19, 2, 79 - 81
• Profiles of Physarum Microplasmodial Phosphatase Activity Crucial to Cytoplasmic Streaming and Spherule Formation., 2019, Okada CY, Nakamura A, Ogawa K, Kohama K, Kaneko TS., Cell Biochem Biophys., 77, 4, 357 - 366
• 2019, 8, 3, 45 - 45
• Effects of intrauterine hyperglycemia on the next generation in diabetic pregnancy model rat, 2019, 19, 2, S - 49-52
• Effect of intrauterine hyperglycemia on brain neurons of rats neonates, 2019, 19, 2, S - 79-81
• Oct. 2018, 81, 10, 1273 - 1277
• Importance of Diet in Gestational Diabetes, Feb. 2018, 53, 2, 4 - 6
• Intrauterine hyperglycemia-induced inflammatory signalling via the receptor for advanced glycation end products in the cardiac muscle of the infants of diabetic mother rats., 2018, Kawaharada, R., Masuda, H., Chen, Z., Blough, E., Kohama, T., and Nakamura, A., Eur. J. Nutr., 57, 8, 2701 - 2712
• NOX1/NADPH Oxidase Expressed in Colonic Macrophages Contributes to the Pathogenesis of Colonic Inflammation in Trinitrobenzene Sulfonic Acid-Induced Murine Colitis., Jan. 2017, Yokota, H., Tsuzuki, A., Shimada, Y., Imai, A., Utsumi D, Tsukahara T, Matsumoto M, Amagase, K., Iwata, K., Nakamura, A., Yabe-Nishimura, C., and Kato, S., J. Pharmacol. Exp. Ther., 360巻, 192 - 200
• Jan. 2017, 17巻, 91 - 95
• 2017, 6, 1, 69 - 69
• The Role of ω-3 Unsaturated Fatty Acids to Protect the Fetal Heart from the Intrauterine Hyperglycemia:Intake of Eicosapentaenoic Acid during Pregnancy for the Diabetic Pregnant Women, 2017, NAKAMURA Akio;KAWAHARADA Ritsuko, KAGAKU TO SEIBUTSU, Japan Society for Bioscience, Biotechnology, and Agrochemistry, 55, 5, 319 - 325
• Beneficial effect of Omega-3 polyunsaturated fatty acids consumption during pregnancy, 2017, 17, 1, 7 - 14
• Oral administration of Dictyostelium differentiation-inducing factor 1 lowers blood glucose levels in streptozotocin- induced diabetic rats., Jun. 2016, Kawaharada, R., Nakamura, A., Takahashi, K., Kikuchi, H., Oshima, Y., and Kubohara, Y., Life Sci., 155巻, 56 - 62
• Calcium-mediated regulation of recombinant hybrids of full-length Physarum myosin heavy chain with Physarum/scallop myosin light chains., Jun. 2016, Zhang, Y., Kawamichi, H., Kohama, K., and Nakamura, A., Acta. Biochim. Biophys. Sin., 48巻, 536 - 543
• Jun. 2015, 15巻, 91 - 95
• Nicotine exposure alters human vascular smooth muscle cell phenotype from a contractile to a synthetic type., Dec. 2014, Yoshiyama, S., Chen, Z., Okagaki, T., Kohama, K., Nasu-Kawaharada. R., Izumi, T., Ohshima, N., Nagai, T., and Nakamura, A., Atherosclerosis, 237巻, 464 - 470
• Interaction of peptide-bound beads with lipo-polysaccharide and lipoproteins., Mar. 2014, Suzuki, M.M., Matsumoto, M., Omi, H., Kobayashi, T., Nakamura, A., Kishi, H., Kobayashi, S., and Takagi, T., J. Microbaiol. Methods, 100巻, 137 - 141
• Jun. 2013, 13巻, 122 - 126
• A maternal diet rich in fish-oil may improve cardiac Akt-related signaling in the offspring of diabetic mother rats., Apr. 2013, Nasu-Kawaharada, R., Nakamura, A., Kakarla, SK., Blough, ER., Kohama, K., and Kohama, T., Nutrition, 29巻, 688 - 692
• Nonmuscle myosin II folds into a 10S form via two portions of tail for dynamic subcellular localization., Feb. 2013, Kiboku, T., Katoh, T., Nakamura, A., Kitamura, A., Kinjo, M., Murakami, Y., and Takahashi. M., Genes to Cell, 218巻, 90 - 109
• Calcium-dependent regulation of the motor activity of recombinant full-length Physarum myosin., Aug. 2012, Zhang Y, Kawamichi H, Tanaka H, Yoshiyama S, Kohama K, Nakamura A., J. Biochem., 152巻, 185 - 190
• Tunicate cytostatic factor TC14-3 induces a polycomb group gene and histone modification through Ca2+ binding and protein dimerization., Jun. 2012, Kawamura, K., Takakura, K., Mori, D., Ikeda, K., Nakamura, A., and Suzuki T., BMC.Cell Biol., 13巻, 1 - 13
• Down-Regulation of Myosin Light Chain Kinase Expression in Vascular Smooth Muscle Cells Accelerates Cell Proliferation: Requirement of Its Actin-binding Domain for Reversion to Normal Rates., Jun. 2012, Wang, H.H., Nakamura, A., Yoshiyama, S., Ishikawa, R., Cai, N., Ye, L.H., Takano-Ohmuro, H., Kohama, K., J. Pharmacol. Sci., 119巻, 91 - 96
• Myosin light chain kinase/actin interaction in phorbol dibutyrate-stimulated smooth muscle cells., Jun. 2011, Thatcher, SE., Fultz, ME., Tanaka, H., Hagiwara, H., Zhang, HL., Zhang, Y., Hayakawa, K., Yoshiyama, S., Nakamura, A., Wang, HH., Katayama, T., Watanabe, M., Lin, Y., Wright, GL., and Kohama, K, J. Pharmacol. Sci., 116巻, 116 - 127
• Effect of cigarette smoke components on vascular smooth muscle cell migration toward platelet-derived growth factor BB., Jun. 2011, Yoshiyama, S., Horinouchi, T., Miwa, S., Wang, H.H., Kohama, K., and Nakamura, A., J. Pharmacol. Sci., 115巻, 532 - 535
• Stimulatory effects of arachidonic acid on myosin ATPase activity and contraction of smooth muscle via myosin motor domain. , Nov. 2010, Katayama, T., Watanabe, M., Tanaka, H., Hino, M., Miyakawa, T., Ohki, T., Ye, L-H., Xie, C., Yoshiyama, S., Nakamura, A., Ishikawa, R., Tanokura, M., Oiwa, K., Kohama, K., Am. J. Physiol. Heart Circ. Physiol., 298巻, 505 - 514
• Purification and characterization of the plasmodial phosphatase that hydrolyses the phosphorylated light chain of Physarum myosin II from Physarum polycephalum., Aug. 2010, Okada, C., Nakamura, A., Tomioka, S., Kohama, K., and Kaneko, T.S, Cell Biol. Int., 34巻, 827 - 835
• Calcium regulation of the ATPase activity of Physarum and scallop myosins using hybrid smooth muscle myosin: The role of the essential light chain., Aug. 2010, Zang, Y., Nakamura, A., Kawamichi, H., Yoshiyama, S., and Katayama, K., FEBS Lett., 584巻, 3486 - 3491
• Feb. 2010, 13巻, 122 - 126
• Calcium wave for cytoplasmic streaming of Physarum polycephalum., Dec. 2009, Yoshiyama, S., Ishigami, M., Nakamura, A., and Kohama, K., Cell Biol. Int., 34巻, 35 - 40
• Calcium regulation of non-kinase and kinase activities of recombinant myosin light-chain kinase and its mutants., Nov. 2009, Xie, C., Zhang, Y., Wang, H., Matsumoto, A., Nakamura, A., Ishikawa, R., Yoshiyama, S., Hayakawa, K., Kohama, K., and Gao, Y., IUBMB Life, 61巻, 1092 - 1098
• Non-kinase Activity of MLCK in Elongated Filopodia Formation and Chemotaxis of Vascular Smooth Muscle Cells toward Sphingosylphosphorylcholine., May 2009, Wang, H-H., Nakamura, A., Yoshiyama, S., Qin, X., Ye, LH., Xe, C., Zhang, Y., Gao, Y., Ishikawa, R., Kohama, K., Am. J. Physiol. Heart Circ. Physiol., 296巻, 1683 - 1693
• The non-kinase activity of myosin light chain kinase in regulating smooth muscle contraction, Mar. 2009, NAKAMURA Akio, Folia Pharmacologica Japonica, The Japanese Pharmacological Society, 133, 3, 144 - 148
• Jun. 2008, Hijikata, T., Nakamura, A., Isokawa, K., Imamura, M., Yuasa K., Ishikawa, R., Kohama, K., Takeda, S., Yorifuji, H., J. Cell Sci., 121巻, 2062 - 2074
• Blebbistatin Inhibits the Chemotaxis of Vascular Smooth Muscle Cells through Breaking the Interaction between Myosin II and Actin., May 2008, Wang, H-H., Tanaka, H., Qin, X., Zhao, T., Ye, L., Okagaki, T., Katayama, T., Nakamura, A., Ishikawa, R., Thatcher, S., Wright, G., and Kohama, K., Am. J. Physiol. Heart Circ. Physiol., 294巻, 2060 - 2068
• Role of non- kinase activity of myosin light- chain kinase in regulating smooth muscle contraction, a review dedicated to Dr. Setsuro Ebashi., Apr. 2008, Nakamura, A., Xie, C., Zhang, Y., Gao, Y., Wang, H-H., Ye, L-H., Kishi, H., Okagaki, T., Yoshiyama, S., Hayakawa, K., Ishikawa, R., Kohama, K., Biochem. Biophys. Res. Commun., 369巻, 135 - 143
• Drebrin attenuates the interaction between actin and myosin-V., Jul. 2007, Ishikawa, R., Katoh, K., Takahashi, A., Xie, C., Oseki, K., Watanabe, M., Igarashi, M., Nakamura, A., Kohama K., Biochem. Biophys. Res. Commun., 359巻, 398 - 1401
• Identification of substrates for transglutaminase in Physarum polycephalum, an acellular slime mold, upon cellular mechanical damage., Jun. 2007, Wada. F., Hasegawa, H., Nakamura, A., Sugimura, Y., Kawai, Y., Sasaki, N., Shibata, H., Maki, M., Hitomi, K., FEBS J, 274巻, 2766 - 2777
• 2P225 Inhibition of the activities of ADF/cofilin by drebrin(Cell biological problems-adhesion, motility, cytoskeleton, signaling, and membrane,Poster Presentations), 2007, Ishikawa Ryoki;Katoh Kaoru;Takahashi Ayumi;Igarashi Michihiro;Nakamura Akio;Kohama Kazuhiro, Seibutsu Butsuri, The Biophysical Society of Japan General Incorporated Association, 47, 0
• 2P229 Roles of actomyosin motility in Ca^<2+>-sensitization of smooth muscle contraction(Cell biological problems-adhesion, motility, cytoskeleton, signaling, and membrane,Poster Presentations), 2007, Kawamichi Hozumi;Wang Chen;Kishi Hiroko;Nakamura AKio;Yoshiyama Shinji;Kohama Kazuhiro;Kobayashi Sei, Seibutsu Butsuri, The Biophysical Society of Japan General Incorporated Association, 47, 0
• Blebbistatin Inhibits Sphingosylphosphorylcholine-Induced Contraction of Collagen-Gel Fiber Populated by Vascular Smooth-Muscle Cells. , Nov. 2006, Katayama T., Yoshiyama, S., Tanaka, H., Wang, H-H., Nakamura, A., and Kohama, K., J. Pharmacol. Sci., 102巻, 1339 - 1342
• Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells after sphingosylphosphorylcholine stimulation. , Sep. 2006, Li. S., Tanaka, H., Wang, H-H., Yoshiyama, S., Kumagai, H., Nakamura, A., Brown, D-L., Thatcher, S-E., Wright, G-L., and Kohama, K., Am. J. Physiol. Heart Circ. Physiol., 291巻, 1262 - 1272
• Vascular endothelium has a local anti-adenovirus vector system and glucocorticoid optimizes its gene transduction., Sep. 2005, Nakamura, A., Hanyuda, Y., Okagaki, T., Takagi, T., Kohama, K., Arterioscler. Thromb. Vasc. Biol., 25巻, 1796 - 1803
• Vanilloid receptor expressed in the sarcoplasmic reticulum of rat skeletal muscle., Jul. 2005, Xin, H., Tanaka, H., Yamaguchi, M., Takemori, S., Nakamura, A., Kohama, K., Biochem. Biophys. Res. Commun., 332巻, 756 - 762
• A Calmodulin-dependent protein kinase from lower eukaryote Physarum polycephalum., Mar. 2005, Nakamura, A., Hanyuda, Y., Okagaki, T., Takagi, T., Kohama, K., Biochem. Biophys. Res. Commun., 328巻, 838 - 844
• Class-Specific Binding of Two Aminoacyl-tRNA Synthetases to Annexin, a Ca2+-and Phospholipid-Binding Protein., Feb. 2005, Shirakawa, T., Nakamura, A., Kohama, K., Hirakata, M., and Ogihara, S., Cell Struct. Funct., 29巻, 159 - 164
• Analyses of expression and localization of two mammalian-type transglutaminases in Physarum polycephalum, an acellular slime mold., Nov. 2004, Wada, F., Ogawa, A., Hanai, Y., Nakamura, A., Maki, M. and Hitomi, K., J. Biochem., 136巻, 665 - 672
• Protein phosphatase 2B dephosphorylates twitchin, initiating the catch state of invertebrate smooth muscle., Sep. 2004, Yamada, A., Yoshio, M., Nakamura, A., Kohama, K., and Oiwa, K., J. Biol. Chem., 279巻, 40762 - 40768
• Nicotinic acetylcholine receptor alpha7 subunit mediates migration of vascular smooth muscle cells toward nicotine., Mar. 2004, Li, S., Zhao, T., Xin, H., Ye, LH., Zhang, X., Tanaka, H., Nakamura, A., and Kohama, K., J. Pharmacol. Sci., 94巻, 334 - 338
• 2004, 20, 176 - 186
• Localization and characterization of the inhibitory Ca2+-binding site of Physarum polycephalum myosin II., Jul. 2003, Farkas, L., Malnasi- Csizmadia, A., Nakamura, A., and Kohama, K., and Nyitray, L., J. Biol. Chem., 279巻, 40762 - 40768
• Myosin light chain kinase stimulates smooth muscle myosin ATPase activity by binding to the myosin heads without phosphorylating the myosin light chain., Jun. 2003, Gao, Y., Kawano, K., Yoshiyama, S., Kawamichi, H., Wang, X., Nakamura, A., and Kohama, K., Biochem. Biophys. Res. Commun., 305巻, 16 - 21
• Expression of vanilloid receptors in rat gastric epithelial cells: role in cellular protection., Mar. 2003, Kato, S., Aihara, E., Nakamura, A., Xin, H., Matsui, H., Kohama, K., and Takeuchi, K., Biochem. Pharmacol., 66巻, 1115 - 1121
• Metal-Free and Ca2+-Bound Structures of a Multidomain EF-Hand Protein, CBP40, from the Lower Eukaryote Physarum polycephalum., Jan. 2003, Iwasaki, W., Sasaki, H., Nakamura, A., Kohama, K and Tanokura M., Structure , 11巻, 75 - 85
• Characterization of Annexin-dependent membrane repair machinery, 2003, Shirakawa T.;Miki N.;Nakamura A.;Kohama K.;Ogihara S., Seibutsu Butsuri, The Biophysical Society of Japan General Incorporated Association, 43, 0
• Identification of mammalian-type transglutaminase in Physarum polycephalum. Evidence from the cDNA sequence and involvement of GTP in the regulation of transamidating activity., Jul. 2002, Wada, F., Nakamura, A., Masutani, T., Ikura, K., Maki, M and Hitomi K., Eur. J. Biochem., 269巻, 3451 - 3460
• Role of the short isoform of myosin light chain kinase in the contraction of cultured smoothmuscle cells as examined by itsdown-regulation., Jul. 2002, Bao. J., Oishi, K., Yamada, T., Liu, L., Nakamura, A., Uchida, M. K., and Kohama, K., Proc. Natl. Acad. Sci. U. S.A., 99巻, 9556 - 9561
• 3L0945 Identification of protein components regulating "catch" state of molluscan smooth musele by in vitro reconstitution experiments, 2002, Yamada A.;Yoshio M.;Nakamura A.;Kohama K.;Oiwa K., Seibutsu Butsuri, The Biophysical Society of Japan General Incorporated Association, 42, 2
• vanilloid receptor channels expressed in human embryonic kidney 293 cells., Oct. 2001, Tsutsumi, S., Tomioka, A., Sudo, M., Nakamura, A., Shirakura, K., and Kohama, K., Nuroscience Lett., 312巻, 45 - 49
• Targeting of myosin light chain kinase in vascular smooth muscle cells, and its implication for drug discovery., Oct. 2001, KOHAMA Kazuhiro;NAKAMURA Akio, Folia Pharmacologica Japonica, The Japanese Pharmacological Society, 118, 4, 269 - 276
• Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction., Jun. 2001, Gao, Y., Ye, L. H., Kishi, H., Okagaki ,T., Samizo, K., Nakamura, A and Kohama K., IUBMB Life, 51巻, 337 - 344
• A highly sensitive method for measurement of myosin atpase activity by reversed-phase high-performance liquid chromatography., Jun. 2001, Samizo, K.,Ishikawa, R., Nakamura, A., and Kohama, K., Anal. Biochem., 293巻, 212 - 215
• Expression and Characterization of Calcium-sensitive Physarum myosin II, 2001, Kawamichi H.;Nakamura A.;Samizo K.;Farkas Laszlo;Nyitray Laszlo;Kohama K., Seibutsu Butsuri, The Biophysical Society of Japan General Incorporated Association, 41, 0
• Tissue distribution of capsaicin receptor in the various organs of rats., Nov. 2000, Onozawa, K., Nakamura, A., Tsutsumi, S., Yao, J., Ishikawa R., and Kohama K., Proc. Japan Acad., 76巻, 68 - 72
• How Can Ca (2+) Selectively Activate Recoverin in the Presence of Mg (2+)? Surface Plasmon Resonance and FT-IR Spectroscopic Studies., Nov. 2000, Ozawa, T., Fukuda, M., Nara, M., Nakamura, A., Komine, Y., Kohama, K., and Umezawa, Y., Biochemistry, 39巻, 14495 - 14503
• Nov. 2000, 9, 3, 114 - 115
• Calcium Binding Properties of Recombinant Calcium-Binding-Protein-40, a Major Calcium Binding Protein of Lower Eukaryote Physarum polycephalum. , Apr. 2000, Nakamura, A., Okagaki, T., Takagi, T., Nakashima K., Yazawa, M., and Kohama K., Biochemistry, 39巻, 3827 - 3834
• The Molecular Structure of the Fastest Myosin from Green Algae, Chara., Apr. 2000, Morimatsu, M., Nakamura, A., Sumiyoshi, H., Sakaba, N., Kohama, K., and Sugie Higashi-Fujime., Biochem. Biophys. Res. Commun., 270巻, 147 - 152
• Assembly of smooth muscle myosin by the 38k protein, a homologue of a subunit of pre-mRNA splicing factor-2., Feb. 2000, Okagaki, T., Nakamura, A., Suzuki, T., Ohmi, K., and Kohama, K., J. Cell Biol., 148巻, 653 - 664
• Stable Transfectants of Smooth Muscle Cell Line Lacking the Expression of Myosin Light Chain Kinase and Their Characterization with Respect to the Actomyosin System, Jan. 2000, Kishi, H., Mikawa, T., Seto, M., Sasaki, Y., Kanayasu, T., Yamaguchi, T., Imamura M., Ito, M., Karaki, H., Bao, J., Nakamura, A., Ishikawa, R., and Kohama K, J. Biol. Chem., 275巻, 1414 - 1420
• Calmodulin modnlates mechanocbemical activities of Charamyosin, 2000, Kakei T.;Morimatsu M.;Nakamura A.;Kohama K.;Higashi-Fujime S., Seibutsu Butsuri, The Biophysical Society of Japan General Incorporated Association, 40, 0
• The molecular structure of the fastest myosin from green algae, Chara, 2000, Morimatsu M.;Nakamura A.;Sumiyoshi H.;Taniguchi H.;Kohama K.;Higashi-Hujime S., Seibutsu Butsuri, The Biophysical Society of Japan General Incorporated Association, 40, 0
• Localizaiton of annexin suggests the possibility that ER is the source of membranes for the protrusive activity in amoeboid mvements, 2000, Kiuchi T.;Miki N.;Nakamura A.;Ogihara S., Seibutsu Butsuri, The Biophysical Society of Japan General Incorporated Association, 40, 0
• Crystallization and preliminary X-ray Diffraction studies of a 40 kDa calcium Binding Protein specifically expressed in plasmodia of Physarum polycephalum., Jul. 1999, Iwasaki, W., Sasaki, H., Nakamura, A., Kohama K., and Tanokura M., J. Biochem., 152巻, 185 - 190
• Myosin light-chain kinase of smooth muscle stimulates myosin ATPase activity without phosphorylating myosin light chain., Jun. 1999, Ye, LH., Kishi, H., Nakamura, A., Okagaki, T., Tanaka, T., Oiwa, K., and Kohama, K., Proc. Natl. Acad. Sci. U. S.A., 96巻, 6666 - 6671
• Apr. 1999, 日本平滑筋学会機関誌, Japan Society of Smooth Muscle Research, 3, 1, J - 57
• Cloning and sequence of tree c-type lectinsfrom body surface mucus of the land slug, Incilaria fruhstorferi., Dec. 1998, Yuasa, J. H., Furuta, E, Nakamura, A., and Takagi, T., Comp. Biochem. Physiol part B, 119巻, 479 - 484
• N-terminal myosin binding fragment of talin., Aug. 1998, Lin, Y., Kishi, H., Nakamura, A., Takagi, T., and Kohama K., Biochem. Biophys. Res. Commun., 249巻, 656 - 659
• The structure and function of actin-binding of myosin light chain kinase of smooth muscle., Dec. 1997, Ye, L. -H., Hayakawa, K., Kishi, H. Imamura, M., Nakamura, A., Okagaki, T., Takagi, T., Iwata, A., Tanaka, T., and Kohama K., J. Biol. Chem., 272巻, 32182 - 32189
• Crystallization of calcium-dependent inhibitory factor, Oct. 1997, IWASAKI W.;SASAKI H.;NAKAMURA A.;KOHAMA K.;TANOKURA M., Biophysics, The Biophysical Society of Japan General Incorporated Association, 37
• Aug. 1996, 19
• Molecular cloning and expression calcium-dependent inhibitory factor in the lower eukaryote, Physarum polycephalum. , Mar. 1996, Nakamura, A., Kitakannto Med. J., 46巻, 113 - 129
• Two-domain hemoglobin of the blood clam Barbatia lima resulted from the recent gene duplication of the single domain d chain., Jan. 1996, Suzuki, T., Kawasaki, Y., Arita, T., and Nakamura., A., Biochem. J., 313巻, 561 - 566
• MOLECULAR CLONING AND EXPRESSION OF CALCIUM-DEPENDENT INHIBITORY FACTOR (CIF) IN THE LOWER EUKARYOTE, PHYSARUM POLYCEPHALUM, 1996, NAKAMURA AKIO, The KITAKANTO Medical Journal, The Kitakanto Medical Society, 46, 2, 113 - 129
• Purification of an ATP-dependent actin-binding protein from a lower eukaryote, Physarum polycephalum, Jul. 1995, Ishikawa, R., Sasaki, Y., Nakamura, A., Takagi, T., and Kohama, K., Biochem. Biophys. Res. Commun., 212巻, 347 - 352
• Isolation, characterization, and primary structure of three major proteins obtained from Mytilus edulis sperm., Sep. 1994, Takagi, T., Nakamura, A., Deguchi, R., and Kyozuka, K., J. Biochem., 116巻, 598 - 605
• Calcium-binding proteins that are involved in the calcium inhibition of the actomyosin system of a lower eukaryote, Physarum polycephalum., Dec. 1993, Kohama K., Ye, LH., and Nakamura, A, Biomed. Res., 2巻, 57 - 62
• Structure of 29-kDa protein from ascidian (Halocynthia roretzi) body wall muscle., May 1993, Takagi, T., Yasunaga, H., and Nakamura, A., J. Biochem., 113巻, 321 - 326
• Primary structure of chain I of the heterodimeric hemoglobin from the blood clam Barbatia virescens., Apr. 1992, Suzuki, T., Nakamura, A., Satoh, Y., Inai, C., Furukohri, T., and Arita, T., J. Protein. Chem., 11巻, 629 - 633
• PCR amplification of cDNA and DNA sequence with biotinylated primer. Application for amplification of invertebrate globins., Mar. 1992, Suzuki, T., Nakamura, A, Mem. Fac. Sci. Kochi Univ. Ser. D (Biol.), 13巻, 35 - 50
• Feb. 1986, 35巻, 1 - 9
• On the molluscan fossils from the Izumi Group of Saijho City in Ehime Prefecture, Shikoku, 1986, Research reports of Kochi University. Natural science, 35, p55 - 61,図1枚

Published Book

• 2024
• 2025
• 2022
• 2021
• ｻｸｾｽ管理栄養士・栄養士養成講座 生化学（第4版）, 23 Aug. 2019, 薗田勝、佐々木康人、中村彰男
• Effects of nicotine contained in tobacco mainstream smoke on vascular smooth muscle cells, 05 Nov. 2018, Nakamura, A
• Oct. 2018
• Fish Oil and Cardiac Akt/mTOR-Mediated Insulin Resistance in Infants with Maternal Diabetes, Nov. 2017, Nakamura, A., and Kawaharada, R.
• May 2017
• The Long-Term Cardiovascular Effects and Safety of Fish Oil among Women with Diabetes and Their Infants. , Jun. 2016, Nakamura, A., and Kawaharada, R., 105 - 129
• The Long-Term Cardiovascular Effects and Safety of Fish Oil among Women with Diabetes and Their Infants. In "Fish Oil: Uses, Properties and Role in Human Health". Edited by Frankie Burton., Jan. 2016, Nova Science Publishers, Inc.New York.
• Cell and molecular biology of the fastest myosins., Jul. 2009, Higashi-Fujime, S. and Nakamura, A., 301 - 347
• Jul. 2009, 144 - 148
• Calcium inhibition of Physarum myosin as examined by the recombinant heavy mero-myos., Mar. 2009, Kawamichi, H., Zhang, Y., Hino, M., Nakamura, A., Farkas, L., Nyitray, L., and Kohama, K., 265 - 272
• Oct. 2001, 452 - 453
• Calcium inhibition of cytoplasmic streaming. , Oct. 2001, Kawamichi, H., Nakamura, A and Kohama K., 221 - 244
• Jun. 2001, 269 - 276
• Calcium regulation of the actin-myosin interaction of Physarum polycepha- lum., Oct. 2000, Nakamura, A., and Kohama K., 53 - 98
• Jan. 2000, 114 - 115
• Calcium inhibition of cytoplasmic streaming In : The molecular basis of calcium action in Biology and Medicine, 2000, Kluwer
• 2000
• Jul. 1999, 73 - 85
• Physarum Cell Culture., Jun. 1999, Kohama, K., and Nakamura, A, 1 - 3
• The molecular anatomy of myosin light chain kinase., May 1999, Kishi, H., Ye, L. -H., Hayakawa, K., Xue, Y., Lin, Y., Nakamura, A., Okagaki, T., and Kohama, K., 15 - 30
• Apr. 1999, 1870 - 1876
• Structure and function of smooth muscle myosin light chain kinase., Apr. 1998, Kishi, H., Ye, LH., Nakamura, A., Okagaki, T., Iwata, A., Tanaka, T., and Kohama, K., 229 - 234

Conference Activities & Talks

• Disease mechanisms in children born to pregnant women with abnormal glucose metabolism, and preventive medicine using functional lipids, 2023, Akio Nakamura
• Effect of hyperglycemia during pregnancy on brain neurons in infants, 2022, Kawaharada, R., Okami, H., Yoshizaki, H., Toriumi, A., Nakamura, A., 22nd IUNS-ICN International Congress of Nutrition
• Effects of extracellular and intracellular advanced glycation end products in an intrauterine hyperglycemic environment on fetal skeletal muscle, 2022, Yoshizaki, H., Kawaharada, R., Okami, H., Toriumi, A., Tsutsumi, S., Nakamura, A., 22nd IUNS-ICN International Congress of Nutrition
• 2021
• Effects of intrauterine exposure of advanced glycation end-products on foetal neuronal cells in a diabetic mother., 2020, Akio Nakamura and Ritsuko Kawaharada, The 7th International Conference on Nutrition and Growth,
• Palmitoleic acids suppress skeletal muscle differentiation in a hyperglycaemic environment, 2021, Yoshizaki, H., Tokunaga, Y., Toriumi, A., Kawaharada, R., Ishida, C., Hori, M., Nakamura, A., The 8th International Conference on Nutrition and Growth
• Effect of hyperglycaemic intrauterine environment on brain neuronal morphology., 2021, Okami H, Nakamura A, Toriumi A, Kawaharada R, The 8th International Conference on Nutrition and Growth
• 01 Aug. 2019
• 09 Aug. 2019
• Effects of saturated fatty acids on skeletal muscle differentiation in an intrauterine hyperglycemic environment., 2020, Tokunaga, Y., Kawaharada, R., Ishida, C., and Nakamura, A., The 93rd Annual Meeting of The Japanese Pharmacological Society
• Effects of AGEs on the rat neuronal cells in the intrauterine hyperglycaemic environment., 16 Mar. 2020, he 93rd Annual Meeting of The Japanese Pharmacological Society（
• 2006
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• Blebbistatin inhibits myosin ATPase and prevents sphingosylphosphorylcholine-induced contraction of collagen-gel fiber populated by vascular smooth muscle., 2007, 5th United States-Japan Workshop on Cellular and Molecular Aspects of Vascular Smooth Muscle Function
• Biochemical aspect of actin-binding proteins in nerve cell growth cones., 2007, The 80th Annual Meeting of The Japanese Pharmacological Society
• Sphingosylphosphorylcholine-induced contraction of collagen-gel fiber populated by vascular smooth-muscle cells., 2007, The 80th Annual Meeting of The Japanese Pharmacological Society
• Blebbistatin blocks migration of vascular smooth muscle cell through inhibiting the ATPase activity of smooth muscle myosin II., 2007, The 80th Annual Meeting of The Japanese Pharmacological Society
• Myosin light chain kinase stimulates smooth muscle myosin ATPase activity by binding to the myosin heads with its non-kinase activity., 2007, The 80th Annual Meeting of The Japanese Pharmacological Society
• Expression and characterization of Ca-sensitive myosin of physarum polycephalum., 2007, The 80th Annual Meeting of The Japanese Pharmacological Society
• Determination of phosphorylation site of smooth muscle myosin light chain kinase by various Ser/Thr kinases, 2007, Joint meeting of the 40th Japanese Society of Developmental Biologists & the 59th Japan Society for Cell Biology
• Blebbistatin inhibits the chemotaxis of vascular smooth muscle cells through breaking the interaction between smooth muscle myosin II and actin., 2008, The Joint Biophysical Society 52nd Annual Meeting and 16th International Biophysics Congress
• The non-kinase activity of myosin light chain kinase in regulating smooth muscle contraction., 2008, The 81st Annual Meeting of the Japanese Pharmacological Society
• Screening of phenotype-specific genes of vascular smooth muscle cell (VSMC) and their characterization., 2008, The 81st Annual Meeting of the Japanese Pharmacological Society
• Brain specific actin-binding protein Drebrin inhibits the cofilin-dependent actin dynamics., 2008, The 81st Annual Meeting of the Japanese Pharmacological Society
• Non-kinase activity of MLCK in elongated filopodia formation and chemotaxis of vascular smooth muscle cells in response to sphingosylphosphorylcholine., 2008, The 81st Annual Meeting of the Japanese Pharmacological Society
• Expression and characterization of the kinase-dead mutants of myosin light chain kinase., 2008, The 81st Annual Meeting of the Japanese Pharmacological Society
• The regulatory effect of Ca2+/calmodulin on the actin-binding activity of smooth muscle myosin light chain kinase., 2008, The 81st Annual Meeting of the Japanese Pharmacological Society
• The non-kinase activity of myosin light chain kinase in regulating smooth muscle contraction., 2008, 10th Meeting of the European Calcium Society
• Calcium inhibition of Physarum myosin in associated with its conformational change, 2008, The Kitakanto Medical Journal
• Actin-bundles as a transporter of nano-sized cargoes., 2008, 2nd International Symposium on Bio-nanosystems,
• Actin-bundles as a transporter of nano-sized cargoes., 2008, In conjunction with 81th Annual meeting of the Japanese Biochemical Society, and 31th Annual Meeting of the Molecular Biology Society of Japan.
• Characterization of the non-kinase activity of smooth muscle myosin light chain kinase., 2008, 48th annual meeting of the American Society for Cell Biology,
• Non-kinase activity of MLCK in inducing filopodia and chemotaxis of vascular smooth muscle cells toward sphingosylphosphorylcholine., 2009, The 82nd Annual Meeting of the Japanese Pharmacological Society
• Cell motility of vascular smooth muscle cells exposed to the cigarette smoke components., 2009, The 82nd Annual Meeting of the Japanese Pharmacological Society
• Sliding of F-actin on myosin II under the conditions fully saturated with variety of actin-binding proteins., 2009, The 82nd Annual Meeting of the Japanese Pharmacological Society
• The analysis of calcium inhibition by constructing hybrid myosins between physarum and smooth muscle myosins., 2009, The 82nd Annual Meeting of the Japanese Pharmacological Society
• Characterization of the kinase-dead mutants of smooth muscle myosin light chain kinase., 2009, The 82nd Annual Meeting of the Japanese Pharmacological Society
• Calcium regulation of non-kinase and kinase activities of myosin light-chain kinase., 2009, 21st IUBMB and 12th FAOBMB International congress of Biochemistry and molecular biology.
• Structure and function of Physarum CBP40, 2009, 21st IUBMB and 12th FAOBMB International congress of Biochemistry and molecular biology.
• Role of essential light chain in regulating the ATPase activities of Scallop and Physarum myosins., 2009, 49th annual meeting of the American Society for Cell Biology
• Phosphorylation of recombinant smooth muscle myosin light chain kinase by various Ser/Thr kinases., 2007, The 80th Annual Meeting of The Japanese Pharmacological Society
• Expression and characterization of recombinant full-length smooth-muscle myosin light chain kinase., 2007, The 80th Annual Meeting of The Japanese Pharmacological Society
• A novel phosphatase from Physarum polycephalum II., 2007, In conjunction with 80th Annual meeting of the Japanese Biochemical Society, and 30th Annual Meeting of the Molecular Biology Society of Japan
• Novel Calcium Regulation of Actin-binding Activity of Smooth Muscle Myosin Light-Chain Kinase. , 2012, 22nd IUBMB & 37th FEBS
• Insulin signaling of diabetic mother rats and their offspring., 2010, The 83Th Annual Meeting of the Japanese Pharmacological Society
• Calcium regulation of the ATPase actvities of scallop and Physarum myosin's: role of essential light chain., 2010, The 83Th Annual Meeting of the Japanese Pharmacological Society
• Role of fold conformation of nonmuscle myosin II., 2012, Joint Meeting of The 45 th Annual Meeting of the Japanese Society of Developmental Biologists &The 64th Annual Meeting of the Japan Society for Cell Biology
• The novel calmodulin-binding site of the smooth muscle muosin light chain kinase., 2010, The 83Th Annual Meeting of the Japanese Pharmacological Society
• The novel calmodulin-binding site of the smooth muscle muosin light chain kinase. , 2010, 11th Meeting of the European Calcium Society
• Effect of a high-fat diet on the skeletal muscle and heart of diabetic mouse. , 2011, The 84Th Annual Meeting of the Japanese Pharmacological Society
• Novel Calcium Regulation of Actin-binding Activity of Smooth Muscle Myosin Light-Chain Kinase. , 2011, The 84Th Annual Meeting of the Japanese Pharmacological Society
• Effect of novel calmodulin- binding site on actin-binding activity of smooth muscle myosin light chain kinase. , 2011, The 84Th Annual Meeting of the Japanese Pharmacological Society
• Calcium regulation of Actin-binding activity of smooth muscle muosin light chain kinase. , 2011, The 17th International Symposium on Calcium-Binding Proteins and Calcium Function in Health and Disease
• Effect of a high-fat diet on the skeletal muscle and heart of diabetic mouse. , 2011, 2011 World Diabetes Congress
• Role of non-kinase activity of myosin light-chain kinase in regulating smooth muscle contraction and migration., 2012, 12th Meeting of the European Calcium Society
• Effect of Fish-oil Diet on Heart of Infant of Diabetic Mother Rats., 2012, 44th Annual Meeting of DPSG
• Effect of EPA on Skeletal and Cardiac muscle of Infants of Diabetic Mother Rats., 2012, 9th International Diabetes Federation Western Pacific Region Congress and 4th Scientific Meeting of Asian Association for the Study of Diabetes.
• Effect of EPA on Skeletal and Cardiac muscle of Infants of Diabetic Mother Rats., 2012, 9th International Diabetes Federation Western Pacific Region Congress and 4th Scientific Meeting of Asian Association for the Study of Diabetes.
• Role of non-kinase activity of vascular smooth muscle myosin light-chain kinase in regulation contraction and migration. , 2012, The 20th Annual Meeting of the Japanese Vascular Biology and Medicine Organization.
• Actin-binding domain of myosin light chain kinase in the proliferation of vascular smooth muscle cells., 2013, The 86Th Annual Meeting of the Japanese Pharmacological Society
• A novel function of myosin light chain kinase in vascular smooth muscle., 2013, The 86Th Annual Meeting of the Japanese Pharmacological Society
• Genetic analysis of vascular smooth muscle cells exposing nicotine, 2013, The 86Th Annual Meeting of the Japanese Pharmacological Society
• Effect of EPA on Skeletal and Cardiac muscle of infants of Diabetic Mother Rats., 2013, The 86Th Annual Meeting of the Japanese Pharmacological Society
• Role of fold conformation of nonmuscle myosin II., 2010, The 62nd Annual Meeting of the Japan Society for Cell Biology
• Effect of nicotine on vascular smooth muscle cells migration and gene expression., 2012, The 85Th Annual Meeting of the Japanese Pharmacological Society
• Effect of EPA on cardiac muscle cell of infants of diabetic mother rats., 2013, 38th FEBS Congress
• Antihypertensive effect and relaxant activity of a post-fermentation tea extract, 2013
• The Molecular Mechanism for Remodeling of Human Aorta Smooth Muscle Cell Exposed to Nicotine. , 2014, The 18th International Vascular Biology Meeting
• A Novel Physarum Phosphatase is related to transition to Sclerotium (Spherule) from plasmodium., 2014, 15thIUBMB&24th FABMB-TSBMB
• Nicotine exposure alters Human Vascular smooth muscle cell phenotype from a contractile to a synthetic type. , 2014, 15thIUBMB&24th FABMB-TSBMB
• The EPA may improve the impaired signaling pathway of the cardiac muscle of infants. , 2015, 12ndAsianCongress of Nutrition
• Eicosapentaenoic acid has improved the impaired insulin-signaling pathway of the cardiac muscle of infants. , 2015, International Conference on Lipid Science & Technology
• Eicosapentaenoic acid supplementation during pregnancy improved the impaired insulin signaling pathway in the cardiac muscle of diabetic mothers. , 2015, International Conference on Lipid Science & Technology
• Myocardial protection by fish oil on infants of diabetic mothers, 2016, 18th World Congress of Food Science and Technology
• EPA improved the infants of diabetic mothers., 2016, 18th World Congress of Food Science and Technology
• Analysis of Protein Modifications by the Active Ingredient from Nicotine- and Tar-Free Cigarette Smoke Extract, 2016, 19th International Vascular Biology Meeting
• Intrauterine hyperglycemia induced impaired insulin signaling and insulin resistance on the cardiac muscle in infant of diabetic mothers., 2016, 5th Conference on Prenatal Programming and Toxicity
• The Effect of Maternal Eicosapentaenoic Acid Supplementation on Infant Cardiovascular Disease., 2016, 5th Annual World Congress of Food and Nutrition-2016
• Intrauterine hyperglycemia induced the inflammatory signalling via the receptor for advanced glycation end products in the cardiac muscle of the infants of diabetic mother rats., 2017, 9th International DIP Symposium on Diabetes, Hypertension, Metabolic Syndrome & Pregnancy of which Maternal Medicine meets Fetal Medicine.

Researcher Profile and Settings

Academic association activities

• International Society for Developmental Origins of Health and Disease
• The Japan Society for DOHaD
• Japan Association for Bioethics

International activity

• Associate Editor: Clinical Nutrition Open Science, Elsevier B.V : Clinical Nutrition Open Science, Grand Duchy of Luxembourg, ESPEN, The European Society for Clinical Nutrition and Metabolism
• Nutrients | An Open Access Journal by MDPI, Special Issue; Early Maternal Nutrition and Its Impact: Unraveling the Short- and Long-Term Health Consequences, Switzerland, MDPI AG, St. Alban-Anlage 66 4052 Basel, Switzerland